EBOO Therapy
- Apr 16
- 7 min read
Updated: 7 days ago
Replenish IV Hydration & Wellness | Patient Education Series
INTEGRATIVE WELLNESS
EBOO Therapy: A Simple Guide to How It
Works and Why It Might Help You
We break down this advanced therapy in plain, everyday language. Replenish IV Hydration & Wellness | Integrative Medicine Practice | Patient Education Series
“Picture sending your blood through a special filter that cleans it, gives it a big shot of oxygen, and helps your immune system fight back — then returns it to your body, refreshed. That’s basically what EBOO does.”
So, what exactly is EBOO?
EBOO stands for Extracorporeal Blood Oxygenation and Ozonation. That’s a mouthful, so let’s break it down:
• Extracorporeal — this just means “outside the body.”
• Blood Oxygenation — your blood gets loaded up with extra oxygen.
• Ozonation — your blood is treated with ozone, a special form of oxygen with three atoms instead of the usual two.
During the treatment, a small amount of your blood is gently drawn out through a tube, run through a medical device that cleans and energizes it, and then returned back into your body — all in a continuous loop. The whole thing works kind of like a water filtration system, but for your blood.
IN PLAIN LANGUAGE
Think of it like running muddy water through a filter. The filter cleans out the junk, adds oxygen, and the clean water comes back out the other side. EBOO does that — but with your blood.
Wait — what is ozone?
You may have heard of the ozone layer that protects Earth from the sun. But medical ozone is completely different from smog or outdoor air pollution. In a medical setting, ozone is made fresh from pure oxygen right there in the clinic. It’s carefully measured and used in very small, controlled amounts— it’s never inhaled.
When ozone touches your blood, it quickly breaks apart and triggers a helpful chain reaction in your body. Instead of being harmful, at the right dose it acts more like a wake-up call — telling your immune system to get to work and your cells to produce more protective antioxidants.
IN PLAIN LANGUAGE
Medical ozone isn’t the scary pollution kind. Think of it as a tiny spark that lights a fire inside your immune system — in a good way. Your body responds by switching on its own natural defenses.
How does it help fight germs and infections?
This is one of the biggest reasons people seek out EBOO. Research shows that ozone can damage or destroy certain germs that get in your blood. Here’s a simple breakdown:
Bacteria Viruses Fungi Parasites
Ozone breaks through
the outer wall of bacteria,
killing them from the
outside in.
Many viruses have a
fatty outer coating.
Ozone damages that
coat so the virus can’t
infect cells.
Ozone weakens the cell
wall of fungi, making it
hard for them to survive
and grow.
Ozone is highly reactive
— this makes it tough on
parasites living in your
blood.
A review in the Journal of Natural Science, Biology and Medicine found that ozone therapy showed real promise against bacteria, viruses, and fungi — especially for patients dealing with stubborn infections that didn’t respond well to regular antibiotics (Elvis & Ekta, 2011).
Another study in Frontiers in
Microbiology found that ozone breaks apart the protective outer layer of certain viruses, making them much weaker (Chirumbolo et al., 2022).
Here’s something important to know: ozone at safe treatment levels works mostly by boosting your own immune system, not by blasting every germ in your body all at once. Think of it less like a bomb and more like calling in backup — it helps your body’s defenses do a better job (Sagai & Bocci, 2011).
IN PLAIN LANGUAGE
EBOO doesn’t replace your antibiotics or other medications. It’s more like giving your immune system a power-up so it can fight harder on its own. It works best as a teammate, not a solo act.
What else can EBOO do for you?
• More energy for your cells. EBOO helps your red blood cells carry and release oxygen more efficiently. More oxygen to your cells means more energy (Di Paolo et al., 2005).
• Less inflammation. Ozone helps calm your body’s alarm system and shift it toward healing mode (Chirumbolo et al., 2022).
• Stronger antioxidant protection. EBOO activates a master switch that tells your body to make more of its own protective antioxidants, including glutathione (Sagai & Bocci, 2011).
• Better circulation. A clinical study showed significant improvements in pain and wound healing in patients with poor blood circulation after EBOO (Di Paolo et al., 2005).
• Blood filtration. EBOO also runs your blood through a filter to remove toxins, leftover debris from dead infections, and other inflammatory waste your body may be struggling to clear.
What actually happens during a session?
1 A small IV is placed in your arm
Just like getting a regular IV drip. Some setups use two sites — one to draw blood out and one to put it back. It’s very similar to how dialysis works.
2
Your blood flows through the device
A steady stream of your blood travels through a sterile, closed machine where it gets treated with a precise oxygen-ozone mixture. Nothing is exposed to open air.
3 It gets filtered at the same time
While the ozone is doing its job, a built-in filter is also removing toxins and waste products from your blood — like a two-in-one wash cycle.
4 Your cleaned blood comes back to you
The treated blood flows back into your body continuously. A full session processes about 2–3 liters of blood and takes around 60–90 minutes.
5 Rest and see how you feel
Most people feel relaxed or a bit more energized after a session. Some feel slightly tired or notice mild detox symptoms in the following hours — this is normal and usually short-lived.
Who is EBOO a good fit for?
EBOO is often a good option for people who:
• Have a chronic infection that hasn’t fully cleared — like Lyme disease, viral hepatitis, or a
persistent bacterial illness
• Are dealing with Long COVID or ongoing fatigue after an illness
• Have an autoimmune condition or chronic inflammation
• Struggle with poor circulation or cardiovascular issues
• Feel constantly tired, foggy, or “off” and haven’t found answers through conventional care
• Want deeper detox support beyond what diet and supplements can offer
■ IMPORTANT SAFETY INFORMATION — PLEASE READ
Not for everyone: People with a condition called G6PD deficiency cannot receive EBOO. This is a genetic condition that affects how your red blood cells work, and ozone can cause serious problems for people who have it. We screen all patients for this before treatment.
Not FDA-approved as a disease treatment: EBOO has not been approved by the FDA to treat, cure, or prevent any disease. We offer it as a complementary therapy — meaning it works alongside your regular medical care, not instead of it.
Tell us about your medications: If you take blood thinners or have a clotting disorder, let us know before scheduling. A full health consultation is required before anyone receives ozone therapy.
What does the research say?
Ozone therapy has been studied for over 100 years and has more than 2,000 published research papers. It’s widely used in Europe and Latin America and is now growing in the U.S. integrative medicine world.
EBOO was first developed in the 1990s in Italy. One clinical trial compared EBOO to a standard vascular drug and found EBOO worked significantly better at healing wounds, reducing pain, and improving how patients felt day to day — with no significant side effects (Di Paolo et al., 2005).
A 2023 study in Inflammopharmacology found that ozone therapy improved immune markers and antioxidant levels in COVID-19 patients, showing it has real measurable effects on the immune system (Ghaleh et al., 2023).
We want to be honest with you: more large-scale studies are still needed to fully confirm everything EBOO can do. The evidence so far is encouraging — but we believe in giving you the full picture, not just the highlights.
A note from our team
At Replenish IV Hydration & Wellness, we don’t offer EBOO as a quick fix or a miracle cure. We offer it because we believe it’s a powerful, thoughtful tool — one that makes the most sense when it’s part of a personalized plan designed just for you.
Before we ever start treatment, we sit down with you, review your health history, and make sure this is the right fit. Your safety and your trust matter to us more than anything.
Have questions? Want to know if EBOO might be right for you? Reach out — we’d love to talk.
REFERENCES
1. Chirumbolo, S., Valdenassi, L., Simonetti, V., Bertossi, D., Ricevuti, G., Franzini, M., & Pandolfi, S. (2022). Mechanisms of
action of ozone therapy in emerging viral diseases. Frontiers in Microbiology, 13, 871645.
2. Di Paolo, N., Bocci, V., Garosi, G., Petrini, G., Guerriero, M., Rossi, S., Branci, S., & Gaggiotti, E. (2005). Extracorporeal blood
oxygenation and ozonation (EBOO): A controlled trial in patients with peripheral artery disease. International Journal of
Artificial Organs, 28(10), 1021–1032. https://doi.org/10.1177/039139880502801010
3. Di Paolo, N., & Bocci, V. (2000). Extracorporeal blood oxygenation and ozonation (EBOO) in man: Preliminary report.
International Journal of Artificial Organs, 23(2), 131–141. https://doi.org/10.1177/039139880002300210
4. Elvis, A. M., & Ekta, J. S. (2011). Ozone therapy: A clinical review. Journal of Natural Science, Biology and Medicine, 2(1),
5. Ghaleh, H. E. G., Izadi, M., Javanbakht, M., Amini, R., & Farahani, A. (2023). Cytokine profile and antioxidants status in
COVID-19 patients: A trial of ozone therapy. Inflammopharmacology, 31, 3029–3036.
6. Sagai, M., & Bocci, V. (2011). Mechanisms of action involved in ozone therapy. Medical Gas Research, 1(1), 29.
7. Bocci, V. A., Zanardi, I., & Travagli, V. (2011). Oxygen-ozone therapy: A critical evaluation. Evidence-Based Complementary
and Alternative Medicine, 2011, 519123. https://doi.org/10.1155/2011/519123
Disclaimer: This content is for educational purposes only and is not medical advice, a diagnosis, or a treatment plan. EBOO has
not been approved by the FDA to treat, cure, or prevent any disease. Please talk to your healthcare provider before starting any
new therapy. Results vary from person to person. EBOO is a complementary therapy — it works alongside conventional care, not
in place of it.
For educational purposes only. Not medical advice.
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